When the word choliy is used in the Old Testament, it always, always, always refers to physical sickness or disease, it never refers to sin.

The Hebrew word for sorrows is makob which means pain. It is translated as pain in Job 14:22 & 33:19.

It is clear that the sickness Isaiah is referring to in Isaiah 53:4 is Jesus bearing our physical sickness. In essence, verse 4 could be rendered this way "Surely He bore our sicknesses, and carried our pains."

Also, Isaiah 53:4 cannot refer to spiritual sickness or sin because as we see from looking at the Hebrews words choliy & makob, these words never refer to spiritual matters, they only refer to physical sickness.

Even Isaiah 53:10 says "Yet it was the will of the Lord to bruise Him; He has put Him to grief and made Him sick." (Amplified Bible)

There is still more proof that Isaiah 53:4 refers to sickness. It lies in Matthew 8:16-17...

"When evening come, many who were demon-possessed were brought to him, and he drove out the spirits with a word and healed all the sick. This was to fulfill what was spoken through the prophet Isaiah: 'He took up our infirmities and carried our diseases.' "

To show that Matthew 8:16-17 does include Jesus bearing our physical sicknesses. Let's break it down.

In verse 16 it says Jesus healed all the sick. That word translated as sick is the Greek word kakos which means to be physically or morally sick. This word is translated in the New Testament as literal sickness.